- Title
- Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies.
- Creator
- O'Keefe, James H.; Tintle, Nathan L.; Venø, Stine Krogh; Chien, Kuo-Liong; Chen, Yun-Yu (Amelia); Egert, Sarah; Feldreich, Tobias Rudholm; Ärnlöv, Johan; Lind, Lars; Forouhi, Nita G.; Geleijnse, Johanna M.; Pertiwi, Kamalita; Harris, William S.; Imamura, F; de Mello Laaksonen, V; Uusitupa, WM; Tuomilehto, J; Laakso, M; Lankinen, MA; Laurin, D; Carmichael, P-H; Lindsay, J; Leander, K; O'Keefe, Evan L.; Laguzzi, F; Swenson, BR; Longstreth, WT; Manson, JE; Mora, S; Cook, NR; Marklund, M; Melo van Lent, D; Murphy, R; Gudnason, V; Sala-Vila, Aleix; Ninomiya, T; Hirakawa, Y; Qian, F; Sun, Q; Hu, F; Ardisson Korat, AV; Risérus, U; Lázaro, I; Samieri, C; Le Goff, M; Attia, John; Helmer, C; Steur, M; Voortman, T; Ikram, MK; Tanaka, T; Das, JK; Ferrucci, L; Bandinelli, S; Tsai, M; Guan, W; Garg, G. Manohar; Garg, P; Verschuren, WMM; Boer, JMA; Biokstra, A; Virtanen, J; Wagner, M; Westra, J; Albuisson, L; Yamagishi, K; Siscovick, DS; Hure, Alexis; Lemaitre, RN; Mozaffarian, D; Bork, Christian Sørensen; Schmidt, Erik Berg
- Relation
- Stroke Vol. 55, Issue 1, p. 50-58
- Publisher Link
- http://dx.doi.org/10.1161/STROKEAHA.123.044281
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2024
- Description
- Background: The effect of marine omega-3 PUFAs on risk of stroke remains unclear. Methods: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome. Results: Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76-0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74-0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81-0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78-0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD. Conclusions: Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.
- Subject
- cerebrovascular disease; atrial fibrillation; fish; fish oil; stroke; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1499599
- Identifier
- uon:54738
- Identifier
- ISSN:0039-2499
- Language
- eng
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